Objective: At present, growth factor-containing products such as enamel matrix derivatives, recombinant bone morphogenetic protein (rh-BMP), recombinant platelet derived growth factor and platelet rich plasma (PRP) have gained increasing attention. PRP is an autologous source of platelet growth factors used to enhance healing of soft and hard tissues. PRP has gained popularity due to its autologous nature, easy procurement and low cost.Review of Literatures: This study focuses on procurement and clinical applications of PRP.Conclusion: Controversy exists regarding the efficacy and applications of PRP and longitudinal studies are required to further elucidate this subject.

Dear Editor: In this article, I review the interesting manuscript titled “, Effects of Platelet-Rich Plasma on Healing of Sphincteroplasty: An Experiment in Rabbit Model”, (1) about application of Platelet-Rich Plasma in anal sphincteroplasty. . .

Background: Platelet-rich plasma (PRP) is plasma of enriched platelets with high concentration of platelet granules and growth factors. The platelet growth factors have a great potential of wound and connective tissue healing used to treat cartilage lesions and retarding the progression of knee osteoarthritis. Objectives: This study was designed to evaluate PRP injection results in knee osteoarthritis. Patients and Methods: This was a case-series study of 39 patients and all of them had three injections of PRP for the involved knee (every two weeks) and they were followed up at two weeks, two months and six months post-injection of PRP. All included patients filled the WOMAC (western Ontario and Mcmaster universities arthritis index) standardized and translated to our national language and culture. We analyzed the collected scores of before initiation of PRP injections, the second week, the second month and the sixth month after injections into the knees. Results: Thirty-nine patients with a mean age of 55. 24 ± 9. 27 years (ranged 40 to 83) were evaluated in this study. Six patients (15. 4%) were male and 33 patients (84. 6%) female. There were significant differences in WOMAC score of patients in two months and six months after injection of PRP compared to before injection. Conclusions: PRP had a great clinical improvement in short-term follow-up for early stages of knee osteoarthritis.